Dr. Smith's ECG Blog

Instructive ECGs in Emergency Medicine Clinical Content

Associate Editors:
— Pendell Meyers & Ken Grauer (2018)
— Jesse McLaren & Emre Aslanger (2022)
— Willy Frick (2024) — Sam Ghali (2025)

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The Effect of Calcium on Severe Hyperkalemia

This patient had a K of 8.1 mEq/L and a very low ionized Calcium of 2.4 mg/dl (normal: 4.4 – 5.2). Both were from a blood sample drawn 13 minutes prior to the following ECG (time zero):

ECG time zero:

There is a near sine wave which is pathognomonic for hyperkalemia.  The QRS duration is 254 ms.

3 g of Calcium gluconate was administered and another ECG was recorded 1 minute later:

The QRS is now 190 ms

Another dose of Calcium was given and this ECG was recorded 2 minutes after the 2nd (3 min after the 1st):

The QRS is not 154 ms.

4 minutes after this, another ECG was recorded:

The QRS is wider again, at 190 ms.

There was rapid release of potassium from this very ill patient, and only a transient effect of Calcium

Learning Point:

Calcium has rapid but reversible effects on QRS width in Hyperkalemia.

See this case of Ventricular Tachycardia from Hyperkalemia which required 15 grams of Ca Gluconate for Stabilization.

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